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Evaluation of Indoxacarb, an Oxadiazine Insecticide for the Control of Pyrethroid-Resistant Anopheles gambiae (Diptera: Culicidae)
Abstract
Owing to the spread of pyrethroid resistance in Anopheles gambiae s.s. (Diptera: Culicidae) and other vector mosquitoes, there is an urgent need to develop alternative insecticides to supplement the pyrethroids for malaria control. Indoxacarb is an oxadiazine insecticide initially commercialized by DuPont for control of agricultural pests. Performance against An. gambiae bearing kdr (pyrethroid and DDT resistance) or Ace-1R insensitive acetylcholinesterase (organophosphate and carbamate resistance) mechanisms was studied using larval and adult bioassays and a simulated experimental hut system (tunnel tests) that allows fuller expression of the behavioral responses to insecticide. Larval and adult bioassays (topical application and cone tests on treated netting) showed a standard probit dosage-mortality response and no evidence of cross-resistance to the kdr and Ace-1R resistance mechanisms. Toxic activity was slow compared with standard insecticides and additional mortality was observed. Indoxacarb induced no excitorepellency in adults. In tunnel tests, indoxacarb induced no inhibition of mosquito penetration or blood feeding through the holed netting, but it induced delayed mortality over 24-96 h. There was > 90% mortality of the kdr strain on netting treated with the 500 mg/m2 dosage, whereas permethin at 500 mg/nm2 only killed 30% of this strain. A mixture of indoxacarb and pyrethroid showed neither synergism nor antagonism. The absence of cross-resistance to current insecticides indicates that indoxacarb has malaria vector control potential as larvicide or adulticide where mosquitoes are pyrethroid resistant.
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New AIs that have been explored and are ripe for development lack the important characteristic of repellency.
“New AIs that have been explored and are ripe for development lack the important characteristic of repellency [6,7].”
From Spatial repellents: from discovery and development to evidence-based validation (2012) · cites this paper as [6]
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Metadata
- Authors
- N’Guessan, R., Corbel, V., Bonnet, J., Yates, A., Asidi, A., Boko, P., Odjo, A., Akogbéto, M., & Rowland, M.
- Affiliations
- Institut de Recherche pour le Développement (FR)
- London School of Hygiene & Tropical Medicine (GB)
- Venue
- Journal of Medical Entomology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-03-01
- Volume
- 44
- Issue
- 2
- Pages
- 270-276
- ISSN
- 0022-2585 (ISSN-L)
- OpenAlex
- W2173137498
- Cited by
- 36
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 2 · 2019: 1 · 2017: 2 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medical Entomology (publishedVersion)
- PubMed (publishedVersion)
- BioOne Complete (BioOne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- indoxacarb, Anopheles gambiae, pyrethroid resistance, kdr mutation, cross-resistance, malaria vector control, larvicidal activity, adulticide, insecticide mixtures, permethrin, tunnel test, insecticide resistance management
- MeSH terms
- Animals, Anopheles, Drug Evaluation, Preclinical, Female, Flight, Animal, Insect Vectors, Insecticide Resistance, Insecticides, Larva, Mosquito Control, Oxazines, Pyrethrins, Time Factors
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